University Events

Description: Topic: Towards in-vivo, non-invasive, label-free, real-time 3D histological imaging via 3D quantitative phase contrast

Speaker: Dr. Francisco Robles, Associate Professor
Wallace H. Coulter Department of Biomedical Engineering
Georgia Tech and Emory University
Atlanta, GA

Zoom Conference Link: https://umassd.zoom.us/j/96205425369
Meeting ID: 962 0542 5369 Passcode: 337041

Abstract:
Quantitative phase imaging (QPI) and refractive index (RI) tomography enable label-free measurements of biological samples with exquisite subcellular contrast and nanometer-scale sensitivity, providing unprecedented access to important histological and biophysical information of cells and tissues non-invasively. However, conventional QPI and RI tomography methods are restricted to thin samples due to their reliance on a transmission-based optical geometry, which hinders their overall clinical utility, particularly for in vivo applications. To overcome this important challenge, my lab has recently developed a technology called quantitative oblique back-illumination microscopy (qOBM), which provides the same level of quantitative cellular and subcellular histological and biophysical information but with epi-illumination. Thus, qOBM can be applied to image large tissues, non-invasively and in vivo, enabling many new applications that were previously out of reach of conventional phase imaging technologies. In this presentation I will discuss the theory and inner workings of qOBM, along with my lab's efforts to apply this technology to novel biomedical and clinical applications, including imaging organoids and assessing brain tumor margins in vivo.

Biography:
Dr. Robles is an Associate Professor at the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. He earned his PhD in Medical Physics from Duke University, followed by a postdoctoral fellowship at Duke in the department of Chemistry. His lab at Georgia Tech and Emory University focuses on developing and advancing label-free optical imaging and spectroscopy technologies to help improve our understanding of biological processes and our ability to identify disease.

The Seminars is open to the public free of charge.

*For further information, please contact Dr. Ana Doblas via email at adoblas@umassd.edu.