EAS PhD Proposal Defense by Cory Hoi Understanding fluid dynamics of surfactant replacement therapy for treating preterm infants with respiratory distress syndrome - A computational study
When: Wednesday,
January 20, 2021
1:00 AM
-
3:00 AM
Where: Online
Description: EAS PhD Program (CSE Option/Mechanical Engineering)
PhD PROPOSAL DEFENSE by Mr. Cory Hoi
Date: January 20, 2021
Time: 1:00 p.m. - 3:00 p.m.
Topic: Understanding fluid dynamics of surfactant replacement therapy for treating preterm infants with
respiratory distress syndrome - A computational study
Zoom Teleconference: https://umassd.zoom.us/j/93637727210?pwd=VjgvWkZyaFRtTml5VG9JcUgxUGpLZz09
Meeting ID: 936 3772 7210
Passcode: 810959
Abstract:
We present 3D multiphase flow simulations of liquid surfactant plug transport through physically representative models of infant lung airway trees. Liquid surfactant instillation into the lung is used to treat respiratory distress syndrome (RDS), affecting preterm infants with a pulmonary surfactant insufficiency. The procedure, commonly known as surfactant replacement therapy (SRT), delivers surfactant plugs with the goal of achieving a uniform film distribution. SRTs effectiveness is tied to the successful plug propagation through each branching airway network. Although effective, SRT has a 35% non-response rate. The difficulty is attributed to the complexity of the human lung, which spans multiple length scales, and that, in turn, complicates predicting the fluid flow in successive airway generations based on plug instillation fluid dynamics at the trachea. To better understand plug flow in each airway generation we have investigated single plug instillation in individual airways (straight tubes) and branching Y-shaped tube models. The results led to correlations between the capillary number, plug film deposition, and plug splitting at bifurcating airways. The preliminary results also include investigation of the effects of multi-plug instillation, plug blockages, and plug rupture on the downstream homogeneity of surfactant in 3-generation airway models. The future work of the proposed PhD research includes simulations of surfactant plug transport in 6- and 8-generation airway models with both Newtonian and non-Newtonian surfactants. The ultimate goal of the proposed research is to develop better understanding of the governing fluid dynamics in upper airway generations to improve SRT.
Acknowledgment:
The research support from the National Science Foundation under CBET Grant No. 1904204 (Fluid Dynamics Program) is gratefully acknowledged.
ADVISOR(S): Dr. Mehdi Raessi, Department of Mechanical Engineering
(mraessi@umassd.edu, 508-999-8496)
COMMITTEE MEMBERS: Dr. Geoffrey Cowles, SMAST/Fisheries Oceanography
Dr. Alfa Heryudono, Department of Mathematics
Dr. Hangjian Ling, Department of Mechanical Engineering
NOTE: All MNE and EAS Students are ENCOURAGED to attend.
PhD PROPOSAL DEFENSE by Mr. Cory Hoi
Date: January 20, 2021
Time: 1:00 p.m. - 3:00 p.m.
Topic: Understanding fluid dynamics of surfactant replacement therapy for treating preterm infants with
respiratory distress syndrome - A computational study
Zoom Teleconference: https://umassd.zoom.us/j/93637727210?pwd=VjgvWkZyaFRtTml5VG9JcUgxUGpLZz09
Meeting ID: 936 3772 7210
Passcode: 810959
Abstract:
We present 3D multiphase flow simulations of liquid surfactant plug transport through physically representative models of infant lung airway trees. Liquid surfactant instillation into the lung is used to treat respiratory distress syndrome (RDS), affecting preterm infants with a pulmonary surfactant insufficiency. The procedure, commonly known as surfactant replacement therapy (SRT), delivers surfactant plugs with the goal of achieving a uniform film distribution. SRTs effectiveness is tied to the successful plug propagation through each branching airway network. Although effective, SRT has a 35% non-response rate. The difficulty is attributed to the complexity of the human lung, which spans multiple length scales, and that, in turn, complicates predicting the fluid flow in successive airway generations based on plug instillation fluid dynamics at the trachea. To better understand plug flow in each airway generation we have investigated single plug instillation in individual airways (straight tubes) and branching Y-shaped tube models. The results led to correlations between the capillary number, plug film deposition, and plug splitting at bifurcating airways. The preliminary results also include investigation of the effects of multi-plug instillation, plug blockages, and plug rupture on the downstream homogeneity of surfactant in 3-generation airway models. The future work of the proposed PhD research includes simulations of surfactant plug transport in 6- and 8-generation airway models with both Newtonian and non-Newtonian surfactants. The ultimate goal of the proposed research is to develop better understanding of the governing fluid dynamics in upper airway generations to improve SRT.
Acknowledgment:
The research support from the National Science Foundation under CBET Grant No. 1904204 (Fluid Dynamics Program) is gratefully acknowledged.
ADVISOR(S): Dr. Mehdi Raessi, Department of Mechanical Engineering
(mraessi@umassd.edu, 508-999-8496)
COMMITTEE MEMBERS: Dr. Geoffrey Cowles, SMAST/Fisheries Oceanography
Dr. Alfa Heryudono, Department of Mathematics
Dr. Hangjian Ling, Department of Mechanical Engineering
NOTE: All MNE and EAS Students are ENCOURAGED to attend.
Contact: > See Description for contact information
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