BMEBT Master of Science Thesis Defense by Morgan Hays
When: Tuesday,
May 25, 2021
12:00 AM
-
2:00 AM
Where: Online
Description: BMEBT Master of Science Thesis Defense by
Morgan Hays
Date: Tuesday, May 25, 2021
Time: 12:00 PM
Topic: Effects of Metformin on Advanced Glycation End Product Formation in Bone under Hyperglycemic Conditions
Zoom Conference Link:
https://umassd.zoom.us/j/91536261424?pwd=RHFvbTlKRm02VHBxaGtHWGFCaWIyQT09
Abstract:
Diabetic patients have a higher rate of bone fracture and bone fragility compared to nondiabetic patients. A characteristic of Type 2 Diabetes Mellitus (T2D) is elevated blood sugar concentrations which means the tissues of the body are in hyperglycemic conditions. High blood sugar has been shown to increase nonenzymatic crosslinks between collagen fibers, known as Advance Glycation End-products (AGEs), in bone tissue and reduce the quality of the bone. Metformin is a commonly prescribed drug for T2D patients to reduce blood sugar spikes but has also been shown to reduce AGEs in other tissues in previous studies. In order to find a way to reduce AGEs in bone, and therefore increase bone quality, our hypothesis is AGE formation will be reduced when bone tissue is incubated in hyperglycemic conditions with metformin.
ADVISOR(S): Dr. Lamya Karim, Department of Bioengineering
(lkarim@umassd.edu, 508.999.8560)
COMMITTEE MEMBERS: Dr. Tracie Ferreira, Department of Bioengineering
Dr. Qinguo Fan, Department of Bioengineering
NOTE: All BMEBT Graduate Students are ENCOURAGED to attend.
Morgan Hays
Date: Tuesday, May 25, 2021
Time: 12:00 PM
Topic: Effects of Metformin on Advanced Glycation End Product Formation in Bone under Hyperglycemic Conditions
Zoom Conference Link:
https://umassd.zoom.us/j/91536261424?pwd=RHFvbTlKRm02VHBxaGtHWGFCaWIyQT09
Abstract:
Diabetic patients have a higher rate of bone fracture and bone fragility compared to nondiabetic patients. A characteristic of Type 2 Diabetes Mellitus (T2D) is elevated blood sugar concentrations which means the tissues of the body are in hyperglycemic conditions. High blood sugar has been shown to increase nonenzymatic crosslinks between collagen fibers, known as Advance Glycation End-products (AGEs), in bone tissue and reduce the quality of the bone. Metformin is a commonly prescribed drug for T2D patients to reduce blood sugar spikes but has also been shown to reduce AGEs in other tissues in previous studies. In order to find a way to reduce AGEs in bone, and therefore increase bone quality, our hypothesis is AGE formation will be reduced when bone tissue is incubated in hyperglycemic conditions with metformin.
ADVISOR(S): Dr. Lamya Karim, Department of Bioengineering
(lkarim@umassd.edu, 508.999.8560)
COMMITTEE MEMBERS: Dr. Tracie Ferreira, Department of Bioengineering
Dr. Qinguo Fan, Department of Bioengineering
NOTE: All BMEBT Graduate Students are ENCOURAGED to attend.
Contact: > See Description for contact information
Topical Areas: Faculty, Students, Students, Graduate, Students, Undergraduate, Bioengineering, Civil and Environmental Engineering, College of Engineering, Computer and Information Science, Co-op Program, Electrical and Computer Engineering, Mechanical Engineering, Physics