BMEBT MS Thesis Defense by Olivia Duclos
When: Monday,
August 7, 2023
11:00 AM
-
1:00 PM
Where: > See description for location
Description: BMEBT MS Thesis Defense by Olivia Duclos
Date: August 7, 2023
Time: 11 am
Zoom: https://umassd.zoom.us/j/94128918744?pwd=YlBKVjNiRTdNNGovOEZUNklGODVYdz09
Title: Effect of Carboxymethyl-Lysine on Diabetic Bone Tissue and Ocy454 Osteocyte Bone Cells
Abstract: Skeletal fragility is a growing concern globally, which negatively affects the quality of one's life and may lead to an increased risk for fracture. There are many factors which play a role in skeletal fragility, including old age and conditions such as osteoporosis and diabetes. Advanced glycation end products (AGEs), which are crosslinks formed by collagen in the bone and free-floating sugars, are one such factor apparent in these conditions that can exacerbate skeletal fragility by altering bone quality. Increased fracture risk in diabetic patients may be linked to an accumulation of AGEs in the bone, which can lead to deteriorated bone health. Carboxymethyl-lysine (CML) is a non-fluorescent AGE that is not as commonly studied but has the potential to be an important marker for AGEs. Not only can AGEs affect the mechanical properties of bone on the tissue level, but at the cellular level as well. Osteocytes are multifunctional bone cells that have a large amount of control on the bone remodeling process. The presence of AGEs can influence the function of osteocytes and lead to alterations in remodeling. The goal of this work is to measure CML in bone tissue as well as determine its impact on osteocytes’ expression of important genes such as receptor activator of nuclear factor kappa B ligand (RANKL), sclerostin (SOST), and receptor for advanced glycation end products (RAGE) in the presence of CML and a hyperglycemic environment.
Advisor: Dr. Lamya Karim, Dept. of Bioengineering (lkarim@umassd.edu)
Committee Members: Dr. Tracie Ferreira, Dept. of Bioengineering
Dr. Milana Vasudev, Dept. of Bioengineering
All BMEBT graduate students are encouraged to attend, and all interested parties are invited.
Date: August 7, 2023
Time: 11 am
Zoom: https://umassd.zoom.us/j/94128918744?pwd=YlBKVjNiRTdNNGovOEZUNklGODVYdz09
Title: Effect of Carboxymethyl-Lysine on Diabetic Bone Tissue and Ocy454 Osteocyte Bone Cells
Abstract: Skeletal fragility is a growing concern globally, which negatively affects the quality of one's life and may lead to an increased risk for fracture. There are many factors which play a role in skeletal fragility, including old age and conditions such as osteoporosis and diabetes. Advanced glycation end products (AGEs), which are crosslinks formed by collagen in the bone and free-floating sugars, are one such factor apparent in these conditions that can exacerbate skeletal fragility by altering bone quality. Increased fracture risk in diabetic patients may be linked to an accumulation of AGEs in the bone, which can lead to deteriorated bone health. Carboxymethyl-lysine (CML) is a non-fluorescent AGE that is not as commonly studied but has the potential to be an important marker for AGEs. Not only can AGEs affect the mechanical properties of bone on the tissue level, but at the cellular level as well. Osteocytes are multifunctional bone cells that have a large amount of control on the bone remodeling process. The presence of AGEs can influence the function of osteocytes and lead to alterations in remodeling. The goal of this work is to measure CML in bone tissue as well as determine its impact on osteocytes’ expression of important genes such as receptor activator of nuclear factor kappa B ligand (RANKL), sclerostin (SOST), and receptor for advanced glycation end products (RAGE) in the presence of CML and a hyperglycemic environment.
Advisor: Dr. Lamya Karim, Dept. of Bioengineering (lkarim@umassd.edu)
Committee Members: Dr. Tracie Ferreira, Dept. of Bioengineering
Dr. Milana Vasudev, Dept. of Bioengineering
All BMEBT graduate students are encouraged to attend, and all interested parties are invited.
Contact: > See Description for contact information
Topical Areas: Faculty, Students, Students, Graduate, Students, Undergraduate, Bioengineering, Civil and Environmental Engineering, College of Engineering, Computer and Information Science, Co-op Program, Electrical and Computer Engineering, Mechanical Engineering, Physics